Endocrine Abstracts

Objectives: Pro-inflammatory cytokine levels are elevated in heart failure and have been implicated in disease progression. Testosterone has been shown to have anti-inflammatory properties and plasma levels may be reduced in men with heart failure. We studied the relation of endogenous testosterone with plasma cytokines in men with chronic heart failure and the effects of testosterone administration.Methods: Baseline plasma levels of total and bio-avail...

Background: Testosterone has been shown to have anti-inflammatory properties and may suppress production of pro-inflammatory cytokines. In this study, we examined the effects of testosterone on the ex-vivo production of the anti-inflammatory cytokine interleukin- (Il-)10 in whole blood from hypogonadal men.Method: 16 men with new diagnosis of hypogondism were studied. Mean age was 61.7 (2.9) years, plasma total testosterone was 6.4 (0.4) nM. Blood was c...